Human Immunodeficiency-deficiency Virus (HIV) is a global pandemic with millions of people affected over the globe. Knowledge about HIV over the last few decades has resulted in improved care and better outcomes for People Living with HIV/AIDS (PLWHA). This increase in knowledge has helped in developing new drugs, preventing transmission, and reducing stigma. But a lot of myths still abound regarding HIV and AIDS and these myths are spurred by a mixture of misinformation and cultural beliefs. To tackle this pandemic of misinformation will require contrasting myths with facts.